MIT's Center for Bits and Atoms is an ambitious interdisciplinary initiative that is looking beyond the end of the Digital Revolution to ask how a functional description of a system can be embodied in, and abstracted from, a physical form. These simple, profound questions date back to the beginning of modern manufacturing and before that to the origins of natural science, but they have revolutionary new implications that follow from the recognition of the computational universality of physical systems. We can no longer afford to ignore nature's capabilities that have been neglected by conventional digital logic; it is at the boundary between the content of information and its physical representation that many of science's greatest technological, economic, and social opportunities and obstacles lie.